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(Details about these programs are not yet available.) These lifestyle support programs will be provided by participating manufacturers

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Interventions: Drug: Semaglutide Drug: Placebo (semaglutide) Primary Outcome Measures Change in maximum walking distance on a constant load treadmill test Ratio to baseline Time frame - From baseline (week 0) to end of treatment (week 52) In light of the STRIDE trial results, Novo Nordisk has submitted a label extension application for Ozempic to the U.S