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Thus, it was suggested that fluoxetine can regulate estrogen synthesis/signaling and cause dysregulation of the estrous cycle, thereby causing sexual dysfunction (Figure 3) ( Figure 3) ( 5 Effects of SSRIs on the reproductive system of aquatic organisms SSRIs are a major class of drugs of environmental concern, and fluoxetine, a psychoactive agent, is one of the best-selling prescription antidepressants in the world, which increases the likelihood of aquatic environmental contamination through municipal, industrial, and hospital discharges, potentially inducing sublethal effects in non-target species

Frequency: Once to twice weekly for maintenance, or more frequently during deficiency correction

Low levels of glutamate is associated with depression and schizophrenia and has been found in lower levels in the anterior cingulate cortex region of the brain in those with psychosis compared to the normal population

In a 68-week randomized, placebo-controlled trial conducted by Bliddal et al