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More importantly, endocrinologists should work coordinately with cardiologists and pharmacologists to establish GLP-1RA-dependent and independent effects in preparation for precisely commencing therapy with GLP-1RAs in suitable targeted patient categories

(54) found that administering GIPR antagonist to healthy humans reduced postprandial insulin secretion and increased glucose excursions more than administering GLP-1R antagonist (GLP-1RA), indicating that endogenous GIP may play a more significant role in stimulating insulin secretion and reducing postprandial plasma glucose excursions compared to endogenous GLP-1

Dosing and titration schedule play a critical role

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 19 million people