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The SURPASS program established efficacy in type 2 diabetes across multiple comparators, including head-to-head superiority versus semaglutide on HbA1c reduction in SURPASS-2 (Fras et al., NEJM, 2021)

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Compounded versions sometimes use other salt forms, such as semaglutide sodium or semaglutide acetate, and they do not go through the same regulatory review that approved generics do