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2/4For tirzepatide, biased activation of the GLP-1R results in increased amount of this receptor on the cell surfaces, while the GIPR agonism result in proportionally higher GIPR internalization and thereby reduced receptor expression compared to the GLP-1R

T., Green, M., Roche, W., Prado-Cabrero, A., Mulcahy, R., & Nolan, J

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When the Ipamorelin-preexposed pituitary cells were later cultured and challenged in vitro with the endogenous hormone GHRH, the Ipamorelin-primed group appeared to exert a clear increase in both the proportion of GH-immunostained somatotrophs and their intracellular growth hormone content