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DNA changes have been described according to NM_019105.7 ( TNXB ), NM_000090.3 ( COL3A1 ), and NM_000088.3 ( COL1A1 )

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SGLT2 inhibitors (sodium-glucose cotransporter-2 inhibitors) such as empagliflozin, dapagliflozin, and canagliflozin represent excellent alternatives, providing cardiovascular and renal protection alongside modest weight loss (typically 2-4 kg)