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Notably, two studies reported that insulin treatment is associated with a higher risk of DPN (39)

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Symptoms of vitamin C deficiency The signs of a Vitamin C deficiency can vary from person to person, but they may include one or more of the following: Rough, dry, damaged, bumpy skin Unexplained weight gain Easy bruising Fatigue, poor mood Bright red hair follicles Chronic stress and inflammation Fingernails spoon shaped with red lines or spots Pain swelling in joints Tooth loss and bleeding gums Slow wound healing Poor immune system Persistent iron deficiency anemia The most common risk factors for vitamin C deficiency are unhealthy diet, anorexia, alcoholism, smoking, severe mental illness, and dialysis