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Using single-cell RNA-sequencing data from mice subjected to transverse aortic constriction (TAC) (Ren et al, 2020), we performed clustering analysis to identify Pomc -, Cpe -, and Pam -expressing cells in major cell types of the heart (Figs

KPV , while primarily anti-inflammatory, contributes by reducing local cytokine-driven endothelial stress, further optimizing conditions for new vessel formation (8)

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