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These compounds intercalate with microbial DNA and chelate essential metals

Notably, heatmap showing the expressions of significantly expressed genes from the pathways of interest was generated by the R package ggplot2 using the metric FPKM, and was colored by the z-score that was computed from the average FPKM of samples in each stage by subtracting the value of the average FPKM in the four stages then dividing by the standard deviation