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That does not sound like much until you consider that losing 10 pounds of lean mass, which is entirely possible on GLP-1 medications without strength training, could reduce your daily calorie burn by 60-100 calories permanently

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Research into glucagons metabolic role has long established its capacity to stimulate hepatic glycogenolysis and gluconeogenesis, but more recent work highlights its effects on lipid metabolism and thermogenesis

One really interesting thing to note is that in this population with more advanced diabetes, 200mg/day of Eriomin was actually this study found an much more helpful for reducing HOMA-IR 11% reduction, compared to only 8% for the 200mg/day group in the previous study