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For example, a meta-analysis revealed the following changes when comparing GLP-1 agonists to placebo: Waist circumference dropped by 5.16 cm BMI decreased by 2.42 kg/m Triglycerides were reduced by 0.20 mmol/L Total testosterone levels fell by 1.33 ng/mL The reduction in waist circumference is particularly impactful because visceral fat is metabolically active and worsens insulin resistance

These compounds are produced when gut microbes ferment certain fibers and prebiotics

Sanofi : While having a presence in the diabetes market, its direct contribution to the GLP-1 receptor agonist segment in Australia might be comparatively smaller than Novo Nordisk or Eli Lilly

26 The majority (67%) of the patients reviewed had a mean baseline HbA1c of 9.5% when therapy was initiated, which supports the theory of lack of action in response to abnormal findings