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Similar content being viewed by others Introduction Loss of cardiomyocytes by apoptotic and/or necrotic cell death contributes to the pathogenesis of multiple forms of heart disease such as ischemia/reperfusion injury (I/R), myocarditis, cardiomyopathy, drug induced cardiotoxicity, and heart failure of diverse etiologies 1, 2

Source: The blood-brain barrier (BBB) is composed of specialized components called neurovascular units or NVUs, which include: Endothelial cells , which line the barrier Astrocytic endfeet , which are part of nerve cells that envelope the blood vessels Basement membrane that lines the epithelial cells Pericytes that provide structural support to the blood vessels, but may also control BBB development and permeability [1] Tight junctions seal the gap between endothelial cells in the same layer