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In the Phase 2 trial, retatrutide was given as a once-weekly subcutaneous injection, starting at a low dose and escalating gradually up to 12 mg weekly

In a novel object recognition (NOR) paradigm, Bbs5 / mice spent less time exploring the novel object than did WT littermates, which was indicative of memory retention deficits (Figure 1G)

Final Thoughts GLP-1 therapy represents an exciting new option for adults struggling with sleep problems, especially those related to excess weight and sleep apnea