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Meanwhile, to further enhance the convenience of wound therapy and achieve controlled drug release, hydrogel-based (e.g., hyaluronic acid, alginate, and gelatin) delivery systems for drugs or exosomes can be established, providing an integrated intervention-delivery solution for precise regulation of ferroptosis in diabetic wounds [49, 87, 89, 98, 108]

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Implementing these multicellular organoid models in lipedema research will enable high-fidelity analysis of how progenitor and immune cells collectively contribute to the pathological tissue architecture