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Many patients find that staying on a stable maintenance dose long-termwith periodic genetic testing to optimize their therapyproduces better health outcomes and greater psychological satisfaction than the stress of discontinuation and rebound cycling

Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)

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