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Whilst treatment failed to reduce amyloid plaque load, liraglutide did prevent the decline in cerebral glucose metabolism after 26 weeks compared to placebo treatment, which suggests that liraglutide may modify disease progression

SURPASS-1 shows that tirzepatide alone, at all doses, was superior to placebo and revealed a dose-dependent reduction of HbA1c by up to 2.07% (p 10% weight loss can be disease modifying and may even lead to disease remission [38]

A 2025 Springer review on the topic confirmed that women with PCOS face unique metabolic challenges, including heightened insulin resistance, compounded by obesity that require targeted, not generic, interventions

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