Some of the drugs whose plasma concentrations are reduced and/or clearance rates are increased (thus resulting in a reduced effective concentration of the drug) by consumption of St Johns wort include: alprazolam (Xanax, Xanor, Alprax, Niravam: treatment of anxiety) amitriptyline (Elavil, Tryptizol, Laroxyl, Sarotex: a tricyclic antidepressant) atorvastatin (Lipitor: treatment for hypercholesterolemia) chlorzoxazone (Paraflex, Parafon Forte, Relaxazone, Remular-S: treatment of muscle spasms) ciclosporin (Cyclosporin: immunosuppressant used by organ transplant patients) debrisoquine (a guanidine derivative for treatment of hypertension) digoxin (Lanoxin, also known as digitalis: treatment of congestive heart failure, CHF) erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole, Ilosone: antibiotic used in upper and lower respiratory infections) fexofenadine (Allegra, Telfast, Fastofen, Tilfur: antihistamine for hay fever and allergy treatment) gliclazide (Glipizide: oral type 2 diabetes drug for lowering blood glucose) imatinib (Gleevec: chemotherapeutic for Philadelphia chromosome positive chronic myelogenous leukemia) indinavir (Crixivan: a protease inhibitor used as a component of highly active antiretroviral therapy, HAART) irinotecan (Camptosar: a topoisomerase I inhibitor used as chemotherapy drug for colo-rectal cancer) ivabradine (Procoralan: management of stable angina pectoris) mephenytoin (Mesantoin: an anticonvulsant) methadone (Symoron, Dolophine, Amidone, Methadose, Physeptone, Heptadon: synthetic opioid used to treat narcotic dependence and withdrawal) midazolam (Versed, Dormicum, Hypnovel: short acting injected sleep inducer for surgery, also produces amnesia) nifedipine (Adalat, Nifedical, Procardia: treatment of hypertension) omeprazole (Prilosec, Zegerid: proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease, PUD, and gastroesophageal reflux disorder, GERD) oral contraceptives quazepam (Doral, Dormalin: treatment of insomnia) simvastatin (Zocor: treatment for hypercholesterolemia) tacrolimus (FK-506 or Fujimycin: immunosuppressant used by organ transplant patients) verapamil (Isoptin, Verelan, Verelan PM, Calan, Bosoptin, Covera-HS: L-type calcium channel blocker for treatment of hypertension), voricoazole (VFEND: antifungal medication) warfarin (Coumadin, Jantoven, Marevan, Lawarin, Waran: anticoagulant)
This formulation features three ways to support healthy glutathione levels: intracellular with S-acetyl L-glutathione (SAG)| intracellular biosynthesis with N-acetyl L-cysteine (NAC)| and extra/intracellular (systemic) support with reduced glutathione (GSH)all combined| for the first time| in a liposomal solution
B Complex Vitamins: This comprehensive blend includes B1, B2, B3, B5, and B6, which collectively enhance energy production, cellular metabolism, stress management, and mood regulation
The compounds most frequently encountered in our study were consistent with those described by other researchers
