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These isoforms have distinct cellular roles but possess high sequence identity (66%) and comparable enzyme properties

44 Upon activation, the D 2 -like receptors will stimulate a variety of processes including acute signaling events (inhibition of adenylyl cyclase, stimulation of K + channels, inhibition of Ca 2+ channels, stimulation of arachidonic acid release) as well as longer-term events (MAP kinase and -arrestin-2/Akt/GSK-3 signaling, and mitogenesis)

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