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In the SURMOUNT-4 trial, tirzepatide achieved weight reductions of up to 22.5% at the highest dose, with some subgroups showing even greater loss compared to semaglutide alone

Beyond the improved glycaemia control, essential for the short term treatment of diabetes (188), different GLP-1RAs are powerful clinical tools for the management of diabetic kidney disease (DKD) (28, 189) non-alcoholic steatohepatitis (NASH) (190), neuroinflammation (191), obesity and cardiovascular disease (192195)

GIP can improve how the body burns fat and works together with GLP-1 to make the treatment for diabetes

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