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In the brain, GLP-1s reduce appetite and cravings (the fundamental mechanism of addictive disease)

NLRP3 inflammasome suppression: IF inhibits the NLRP3 inflammasome, a key mediator of inflammation in RA 39

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Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I et al (2021) Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia