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Gastro-oesophageal reflux is listed as a common side effect with some GLP-1 medications, affecting up to 1 in 10 people

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Improved liver enzymes: ALT and AST (markers of liver inflammation) typically decrease with treatment

The release of cathepsin D induced necroptosis through the proteolysis of caspase-8 and promotion of RIPK1 activation, implying that lysosomal dysfunction might be crucially involved in the onset of necroptosis 9