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It is hydroxylated into the catechol estrogens 2-hydroxyestradiol and 4-hydroxyestradiol and into estriol (16-hydroxyestradiol), reactions which are catalyzed by cytochrome P450 enzymes predominantly in the liver, but also in various other tissues

When GIP and glucagon receptor activation are added, appetite regulation may become broader and more durable, although the relative contribution of each receptor remains incompletely defined

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10.1159/000521264(Accessed September 18, 2025)