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Cullen, T
A large-scale 20-year cohort study of 458 cisplatin-treated testicular cancer survivors further demonstrated that serum platinum levels remained significantly elevated compared with surgery-only, chemotherapy-naive controls even 20 years post-chemotherapy, with a clear dose-dependent positive correlation between residual platinum levels and cumulative cisplatin dose (Hjelle et al
The active metabolite of folate, 5-methyltetrahydrofolate (5-MTHF, L-methylfolate), participates in re-methylation of the amino acid metabolite homocysteine, creating methionineThere are few intervention studies of folic acid or 5-MTHF as a stand-alone treatment for depression related to folate deficiency
Phase IV (Post-Market): Ongoing monitoring of the treatments long-term effects in the general population
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