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Significant improvements in fasting glucose or weight may justify more conservative escalation, while absence of improvement may prompt discussion of dose timing or medication adherence

But for someone relying on natural GLP-1 levels, entering ketosis could temporarily reduce one of the hormones that helps control appetite

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The resulting 2.5% SSA plasma supernatant was collected into 1.5 mL microcentrifuge tubes, flash frozen on dry ice, and stored at 80 o C for future analysis