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Upon endocytosis by the endothelial cells, albumin binds to the Fc receptor (FcRn) during endosomal acidification, which sorts the intracellular trafficking of the albumin away from degradative lysosomes and back to the plasma membrane where it can once again reenter the general circulation

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This concept can be confirmed by immunostaining with the VE1 antibody, specific for BRAF V600E that reveals the presence of this abnormality in each melanocyte of a BRAF- mutated nevus