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Many patientsespecially those with localized tumorsmay die of other illnesses without ever having suffered disability from prostate cancer, even if managed conservatively without an attempt at curative therapy.[3,4] In part, these favorable outcomes are likely the result of widespread screening with the prostate-specific antigen (PSA) test, which can identify patients with asymptomatic tumors that have little or no lethal potential.[5] The prevalence of clinically indolent tumors is estimated at 30% to 70% in men older than 60 years, based on autopsy series of men dying of causes unrelated to prostate cancer.[6,7] Because diagnostic methods have changed over time, any analysis of survival after treatment of prostate cancer and comparison of the various treatment strategies is complicated by evidence of increasing diagnosis of nonlethal tumors

Health 50 , 471481 (2022)

doi: 10.1016/S0140-6736(24)01614-3 98 TomovD