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Of the six cases, three (Cases 1, 3, and 4) showed lesions in both tissues that were positive for GLP- 1R expression, one showed lesions in which one of the tissues was positive (Case 2), and two were negative (Cases 5 and 6)

Intestinal dysbiosis, which refers to an imbalance in the gut microbiome, has been linked to several health conditions, including obesity

In patients with heart failure, although the underlying condition can predispose to lactic acidosis, existing evidence suggests that metformin use is associated with improved outcomes rather than increased risk