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The eight RCTs were published between 2010 and 2021 and conducted in three countries, including Iran ( n = 5) [13, 1618, 35], Korea ( n = 2) [32, 33], and Italy ( n = 1) [34]

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GSK3 overexpression abrogates the protective effects of semaglutide, while GSK3 knockdown mimics its actions, establishing GSK3 as a mediator of GLP-1

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