SQ20B cells, SQ20B+5 Gy carbon ion radiation, SQ20B+10 Gy X-rays, SQ20B+GSH depletion, SQ20B+GSH depletion+5 Gy carbon ion radiation, SQ20B+GSH-depletion+10 Gy X-rays, SCC61, SCC61+5 Gy carbon ion radiation, SCC61+10 Gy X-rays
Prospective studies and randomized trials are currently underway to generate more sophisticated data for inclusion within the screening pathway (203)
As with many nutrients, both the form and the dose matter, and the optimal approach depends on an individuals nutritional status, genetic background and clinical circumstances
There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH