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Reduction in Cardiovascular Risk: The SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events with semaglutide in overweight and obese patients with established CVD independent of diabetes status or the degree of weight loss achieved

Valproate-induced acute liver failure and liver-related deaths have been reported in patients with hereditary neurometabolic syndromes caused by mutations in the gene for mitochondrial DNA polymerase (POLG) (e.g., Alpers-Huttenlocher Syndrome) at a higher rate than those without these syndromes

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While each persons experience can vary, research and patient feedback have helped identify practical pros and cons of the most common areas used for subcutaneous dosing: the stomach, thigh, and upper arm