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Timing can affect how well both work together

Severe niacin deficiency, known as pellagra, has been historically associated with poverty and consumption of a diet predominantly based on corn, which is low in bioavailable niacin (25, 26)

In mice, the loss of JNK1 and JNK2 led to more severe age-related OA and ageing of cartilage and synovium (Loeser et al., 2020), an indication that JNK is a detrimental regulator of joint degeneration

Aim for at least 810 glasses of water daily, and increase this if you exercise or live in a dry climate