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If you're taking GLP-1 medications like Ozempic or Mounjaro (Tirzepatide), youve probably heard the term GLP-1 face. Its a real phenomenon yet completely normal

FXR activation inhibits BAs production and BAs influx, promotes BAs efflux, and thus alleviates the excessive accumulation of BAs caused by liver disease

That fragment acts on a target the same Washington State group helped pin down: the so-called AT4 receptor, which was identified as IRAP, insulin-regulated aminopeptidase, an enzyme rather than a classical receptor (Albiston et al., J Biol Chem 2001)

The redox couple GSH/GSSG represents a critical determinant of the cells antioxidant defense capacity [12]