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In parallel, studies using human iPSC-derived brain organoids reveal that esketamine induces rapid, concentration-dependent metabolic reprogramming, characterized by transient suppression of OXPHOS and glycolysis, accompanied by altered intracellular energy status, Ca signaling, and neuronal excitability [138]
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Superior Sagittal Sinus, Portal and Caval Vein and Abdominal Aorta Pressure Recording Ligation of the superior sagittal sinus immediately overwhelms normal (negative) pressure, and induces the increased (positive) pressure, along with the severe portal and caval hypertension (portal hypertension exceeding caval hypertension), and aortal hypotension, persisting throughout the entire experimental period (Figure 5)