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To confirm whether Med14 was an integral link between GLP-1 drugs and ultimate changes in gene expression and pancreatic beta cell behavior, the researchers decided to mutate Med14, making the protein resistant to phosphorylation

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The target

Carnitine supplementation may have beneficial effects on glucose homeostasis also by modulating the expression of genes involved in insulin signaling pathway, changing the expression of gluconeogenic and glycolytic enzymes, regulating the intra-mitochondrial acyl-CoA/CoA ratio, and modulating the activity of pyruvate dehydrogenase complex (Steiber et al., 2004[46])