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In light of this potential significant safety issue, the development of Lotiglipron has been discontinued, meaning the drug did not progress to further clinical trial stages to evaluate its efficacy and safety

One region is termed as G-site, which is hydrophilic in nature and binds the physiological substrate GSH, and another region is the H-site, which assists in binding of electrophilic substrates by providing a hydrophobic environment ( FIGURE 1 GSTs and Stress Response Glutathione S-transferases are known to express at different stages of plant development

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Hrelec M, Klicek R, Brcic L, et al