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However, if noticeable alterations occur in the size, shape, or color of a melanocytic nevus, such as enlargement, elevation, or uneven pigmentation, medical intervention is necessary, and prompt medical attention should be sought.

[1] It is suggested that delayed processing of secreted lipids in the interfollicular epidermis and between the corneocytes in the upper parts of the hair follicles may be the cause of an impairment in the permeability of the epithelial barrier/Lipid Lamellae