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The NAA produced in neurons is transported to the cytosol of oligodendrocytes (as well as astrocytes) via the action of the sodium-dicarboxylate cotransporter encoded by the SLC13A3 gene
The synthetic triterpenoid compound bardoxolone methyl (bardoxolone) has also been studied for potential therapeutic applications in various diseases, such as in clinical trials for the treatment of chronic kidney disease, type 2 diabetes, and Alport syndrome [460,461,462,463]
It's usually a short-lived phase as the body cleans house and rebalances
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