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14 #### For ARNI-eligible individuals who cannot take due to cost or intolerance

Results Search Results A total of 17 studies were identified by literature search [one with two eligible contrasts ( Pooled Effect-Size Between-studies heterogeneity was not significant for VR ( I 2 = 12.8%, Cochran's Q = 24.14, p = 0.19) and CVR ( I 2 = 0%, Cochran's Q = 14.33, p = 0.76) estimates, but as expected, for SMDH there was a significant between-studies heterogeneity ( I 2 = 47.4%, Cochran's Q = 37.15, p = 0.008)

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