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The signs of DVT include: More prominent veins near the skins surface Pain or tenderness in the leg or arm, sometimes only if standing or walking Red, darkened or discolored skin Swollen arm or leg (sometimes happening abruptly) More warmth than average in the swollen area Some people dont realize they have DVT until the clot travels from their leg or arm to their lungs and causes a pulmonary embolism (PE).The symptoms of PE include: Chest pain Coughing up blood Difficulty breathing Fainting Lightheadedness Those with DVT symptoms should call their doctor or go to the emergency room immediately to help avoid further complications

It also influences gastric motility, lipid metabolism, fat absorption, and even cardiovascular and neurological function

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However, it is important to remember that not all fusions are equally conducive to expression of the corresponding kinase