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There was a progressive decrease of the proportion of patients at target for each 0.5% increase in baseline HbA1c, ranging from 57.8% for HbA1c 7.5% to 20.8% for HbA1c 10% (p for trend 9.0% with no further decrease, whereas for non-insulin drugs the relationship was continuous without any evidence of plateau 5

New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine

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Moreover, iron is part of the prosthetic group of catalases, key antioxidant enzymes that counteract oxidative stress by catalyzing the reduction and detoxification of hydrogen peroxide