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The general reaction involves formation of an unsymmetrical disulfide from the protectable protein (RSH) and GSH: [24] RSH + GSH + [O] GSSR + H 2 O Glutathione is also employed for the detoxification of methylglyoxal and formaldehyde, toxic metabolites produced under oxidative stress

Starting even before the new legislation was enacted, and continuing for several years thereafter, DoD and the major SBIR-funding components moved to address the need for improved commercialization