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Ensuring efficacy, safety, and durability comparable to injectable GLP-1 RAs while minimizing adverse effects, particularly gastrointestinal discomfort, is essential

GLP-1 medications like Ozempic, Wegovy and Zepbound, originally developed for Type 2 diabetes, are now widely used to fight obesity

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Clinical trial data and FDA labeling information indicate that gastrointestinal effects are dose-dependent and typically most pronounced during initial treatment or dose escalation