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The core difference is this: phentermine pushes the nervous system to switch off hunger with an amphetamine-like stimulus, while semaglutide works on a hormonal pathway your body already uses to signal that youve had enough

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On August 27, 2025, the FDA approved the first generic version of liraglutide (Saxenda) for weight loss in adults and adolescents with obesity and adults with overweight and at least one weight-related comorbid condition