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Stimulation of Insulin Secretion (-cells) When GLP-1 RAs bind to receptors on pancreatic -cells, they activate adenylate cyclase (AC), increasing intracellular cyclic AMP (cAMP)

Although there have not been definitive studies demonstrating the same role for adiponectin in the non-pregnant state, animal studies have shown that adiponectin secretion is significantly suppressed by prolactin in mice in vivo and in human adipose tissue in vitro (70)