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Although Pol- has relatively low affinity for these analogues (100), their incorporation causes premature chain termination during mtDNA replication, leading to mtDNA depletion, reduced expression of -encoded OXPHOS subunits, and ultimately impaired ETC function and ATP production (101103)

Research Considerations and Peptide Purity When conducting research with peptides like MOTS-c, several important factors must be considered to ensure the validity and reliability of findings

This material is suitable for structured research involving peptide identification, molecular characterization, stability assessment, purity evaluation, and other analytical procedures