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Endoplasmic reticulum stress induction and ERK1/2 activation contribute to nefazodone-induced toxicity in hepatic cells

Patients can present with the following signs & symptoms: CNS (areflexia, asthenia, ataxia, blurred vision, disorientation, dizziness, drowsiness, hyporeflexia, slurred speedh, somnolence, staggering, tiredness, coma) Cardiovascular (initial hypertension, followed by long-lasting hypotension , bradycardia , premature ventricular beats) the peripheral actions of xylazine cause an initial increase in blood pressure, followed by central effects that result in a long-lasting hypotensive effect, accompanied by bradycardia and reduced cardiac output (Hoffman et al, 2001)

Homocysteine metabolism is closely related to adequate intake of B vitamins, especially B6, B9 (folic acid), and B12

This results in increased antioxidant protection, better detoxification support, and enhanced immune health