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Abl: Abelson murine leukemia viral oncogene homolog 1 AMP: adenosine monophosphate AMPK: AMP activated protein kinase AR: androgen receptor Bcr: breakpoint cluster region protein BPH: benign prostatic hyperplasia DAG: diacylglycerol EC: esophageal cancer EGF: epidermal growth factor ESCC: esophageal squamous cell carcinoma GAP: guanidine nucleotide exchange factor GA: gastric adenocarcinoma GC: gastric cancer GCA: gastric cardia adenocarcinoma GEF: guanine nucleotide exchange factor GPCR: G-protein coupled receptors GTP: guanosine-5'-triphosphate GWAS: genome-wide association study HNSCC: head and neck squamous cell carcinoma IL: interleukin IP3: inositol-1,4,5-phosphate LD: linkage disequilibrium LPA: lysophosphatidic acid MAPK: mitogen-activated protein kinase MEF: mouse embryonic fibroblasts MMP: matrix metalloproteinase NF-B: nuclear factor kappa light chain enhancer of activated B cells NSCLC: non-small cell lung carcinoma PDGF: platelet-derived growth factor receptor PH domain: pleckstrin-homology domain PI3K: phosphoinositide 3-kinase PIP2: phosphoinositol 4,5-bisphosphates PKC: protein kinase C PLC: phospholipase C RA domain: Ras-associating domain RTK: receptor tyrosine kinases shRNA: small hairpin ribonucleic acid S1P: sphingosine-1-phosphate SNP: single nucleotide polymorphisms STAT3: signal transducer and activator of transcription 3 TCCB: transitional cell carcinoma of bladder TLR-4: Toll-like receptor 4 TNF-: tumor necrosis factor TPA: 12-O-tetradecanoyl-phorbor-13-acetate This works was supported by BMBF grant (ZIK OncoRay