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A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia

To further evaluate the effect of eye drops on the metabolomic profile of the aqueous humor, we performed association analyses with and without eye drops (Supplementary Table 4)

The move from injectables to solid oral dose reflects a broader shift toward medicines that are easier to use, easier to scale and better suited to long-term patient needs

600mg is a reduced glutathione injection from Daehan New Pharm in South Korea