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In addition, we do not see the same magnitude of cardiovascular risk reduction from equivalent weight loss from calorie restriction. In a published expert reaction to the SELECT trial, Tricia Tan, consultant in diabetes, endocrinology and metabolic medicine at Imperial College London and NHS Trust, highlighted the subsequent implication for National Institute for Health and Care Excellence (NICE) guidance, which currently recommends stopping semaglutide treatment in patients who have not lost more than 5% of weight after six months

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If traveling west, shift one to two hours later