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I then contacted the Department of Health at Skipton House in London and after explaining the problem was put through to the Distribution Team who are very concerned about any local shortage and yesterday (Friday) they had contacted all licensed manufacturers of B12 and asked for a written explanation of why there seems to be local shortages

B12 overdoses are unusual

Temperature shock can cause precipitation, where the peptide crashes out of solution and forms visible particles that indicate permanent damage

Andr J, Monreal D, Martinez de Tejada G, Olak C, Brezesinski G, Gomez SS, Goldmann T, Bartels R, Brandenburg K, Moriyon I: Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens